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1

Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation §

Geschwindner, Stefan, Olsson, Lise-Lotte, Albert, Jeffrey S., Deinum, Johanna, Edwards, Philip D., de Beer, Tonny, Folmer, Rutger H. A.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 244 KB

english, 2007

2

Test characteristics of the aldosterone-to-renin ratio as a screening test for primary aldosteronism

Jansen, Pieter M., van den Born, Bert-Jan H., Frenkel, Wijnanda J., de Bruijne, Emile L.E., Deinum, Jaap, Kerstens, Michiel N., Smulders, Yvo M., Woittiez, Arend Jan, Wijbenga, Johanna A.M., Zietse, R

Journal:

Journal of Hypertension

Année:

2014

Langue:

english

Fichier:

PDF, 611 KB

english, 2014

3

Determinants of blood pressure reduction by eplerenone in uncontrolled hypertension

Jansen, Pieter M., Frenkel, Wijnanda J., van den Born, Bert-Jan H., de Bruijne, Emile L.E., Deinum, Jaap, Kerstens, Michiel N., Arnoldus, Joyce H.A., Woittiez, Arend Jan, Wijbenga, Johanna A.M., Ziets

Journal:

Journal of Hypertension

Année:

2013

Langue:

english

Fichier:

PDF, 295 KB

english, 2013

4

Biosensor Analysis of Drug–Target Interactions: Direct and Competitive Binding Assays for Investigation of Interactions between Thrombin and Thrombin Inhibitors

Robert Karlsson, Mari Kullman-Magnusson, Markku D. Hämäläinen, Annika Remaeus, Karl Andersson, Peter Borg, Erika Gyzander, Johanna Deinum

Journal:

Analytical Biochemistry

Année:

2000

Langue:

english

Fichier:

PDF, 202 KB

english, 2000

5

Biosensor Analysis of Drug–Target Interactions: Direct and Competitive Binding Assays for Investigation of Interactions between Thrombin and Thrombin Inhibitors: Volume 278, Number 1 (2000), pages 1–13

Robert Karlsson, Mari Kullman-Magnusson, Markku D. Hämäläinen, Annika Remaeus, Karl Andersson, Peter Borg, Erika Gyzander, Johanna Deinum

Journal:

Analytical Biochemistry

Année:

2001

Fichier:

PDF, 13 KB

2001

6

A Thermodynamic Characterization of the Binding of Thrombin Inhibitors to Human Thrombin, Combining Biosensor Technology, Stopped-Flow Spectrophotometry, and Microcalorimetry

Johanna Deinum, Lars Gustavsson, Erika Gyzander, Mari Kullman-Magnusson, Åsa Edström, Robert Karlsson

Journal:

Analytical Biochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 152 KB

english, 2002

7

Probing the interaction of coagulation factors with phospholipid vesicle surfaces by surface plasma resonance

Angelica Wikström, Johanna Deinum

Journal:

Analytical Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2007

8

Design and synthesis of thrombin inhibitors

D. Michael Jones, Butrus Atrash, Ann-Catrine Teger-Nilsson, Erica Gyzander, Johanna Deinum, Michael Szelke

Journal:

International Journal of Peptide Research and Therapeutics

Année:

1995

Langue:

english

Fichier:

PDF, 498 KB

english, 1995

9

Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine and desacetamidoisocolchicine

Ulf Berg, Johanna Deinum, Per Lincoln, Jan Kvassman

Journal:

Bioorganic Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 775 KB

english, 1991

10

Synthesis and biological activity of potent, low molecular weight renin inhibitors

JAVIER SUEIRAS-DIAZ, D. MICHAEL JONES, MICHAEL SZELKE, JOHANNA DEINUM, LENNART SVENSSON, CHRISTER WESTERLUND, MORGAN SOHTELL

Journal:

Chemical Biology & Drug Design

Année:

1997

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1997

11

The Mechanism of Binding of Low-Molecular-Weight Active Site Inhibitors to Human α-Thrombin

Nilsson, Thomas, Sjöling-Ericksson, Åsa, Deinum, Johanna

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 923 KB

english, 1998

12

Expression and Characterization of Recombinant Ecarin

Anna Jonebring, Ute Lange, Elke Bucha, Johanna Deinum, Margareta Elg, Ann Lövgren

Journal:

The Protein Journal

Année:

2012

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2012

13

The reaction of mercaptans with tyrosinases and hemocyanins

Roland Aasa, Johanna Deinum, Konrad Lerch, Bengt Reinhammar

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure

Année:

1978

Langue:

english

Fichier:

PDF, 729 KB

english, 1978

14

Metal analysis by energy dispersive X-ray fluorescence of bovine brain tubulin and microtubule-associated proteins prepared by phosphocellulose chromatography

Margareta Wallin, Johanna Deinum, Anders Rindby, Carl Lagercrantz

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure

Année:

1980

Langue:

english

Fichier:

PDF, 471 KB

english, 1980

15

Spatial separation of the two essential thiol groups and the binding site of the exchangeable GTP in brain tubulin: A spin label study

Johanna Deinum, Margareta Wallin, Carl Lagercrantz

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure

Année:

1981

Langue:

english

Fichier:

PDF, 613 KB

english, 1981

16

Diethylstilbestrol induces metaphase arrest and inhibits microtubule assembly

Beryl Hartley-Asp, Johanna Deinum, Margareta Wallin

Journal:

Mutation Research Letters

Année:

1985

Langue:

english

Fichier:

PDF, 367 KB

english, 1985

17

Binding to tubulin of an allocolchicine spin probe: interaction with the essential SH groups and other active sites

Johanna Deinum, Per Lincoln

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1986

Langue:

english

Fichier:

PDF, 593 KB

english, 1986

18

Effects of proteolysis of the extending parts of the high-molecular-weight microtubule-associated proteins on interactions between microtubules

Bo Fridén, Jerker Nordh, Margareta Wallin, Johanna Deinum, Bengt Nordén

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1988

Langue:

english

Fichier:

PDF, 3.72 MB

english, 1988

19

Cis-trans isomerization of an angiotensin I-converting enzyme inhibitor. An enzyme kinetic and nuclear magnetic resonance study

Anders Skoglöf, Ingemar Nilsson, Stina Gustafsson, Johanna Deinum, Per-Olof Göthe

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1990

Langue:

english

Fichier:

PDF, 817 KB

english, 1990

20

Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator

Petter Björquist, Maria Brohlin, Johanna Ehnebom, Maria Ericsson, Charlotte Kristiansen, Gunnar Pohl, Johanna Deinum

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1994

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1994

21

Characterisation of the complex of plasminogen activator inhibitor type 1 with tissue-type plasminogen activator by mass spectrometry and size-exclusion chromatography

Mats Strömqvist, Karl-Erik Karlsson, Petter Björquist, Jan-Olof Andersson, Mona Byström, Lennart Hansson, Thord Johansson, Johanna Deinum

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1996

Langue:

english

Fichier:

PDF, 628 KB

english, 1996

22

Epitopes on plasminogen activator inhibitor type-1 important for binding to tissue plasminogen activator

Petter Björquist, Johanna Ehnebom, Tord Inghardt, Johanna Deinum

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1997

Langue:

english

Fichier:

PDF, 226 KB

english, 1997

23

Protein movement during complex-formation between tissue plasminogen activator and plasminogen activator inhibitor-1

Petter Björquist, Johanna Ehnebom, Johanna Deinum

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1999

Langue:

english

Fichier:

PDF, 243 KB

english, 1999

24

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

Yafeng Xue, Petter Björquist, Tord Inghardt, Marcel Linschoten, Djordje Musil, Lennart Sjölin, Johanna Deinum

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 1.38 MB

english, 1998

25

Effect of estramustine phosphate on the assembly of trypsin-treated microtubules and microtubules reconstituted from purified tubulin with either tau, MAP2, or the tubulin-binding fragment of MAP2

Bo Fridén, Margareta Wallin, Johanna Deinum, Veena Prasad, Richard Luduena

Journal:

Archives of Biochemistry and Biophysics

Année:

1987

Langue:

english

Fichier:

PDF, 753 KB

english, 1987

26

The effect of gossypol on fast axonal transport and microtubule assembly

Martin Kanje, Per Ekström, Johanna Deinum, Margareta Wallin

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

1986

Langue:

english

Fichier:

PDF, 417 KB

english, 1986

27

The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent

Bo Fridén, Mikael Rutberg, Johanna Deinum, Margareta Wallin

Journal:

Biochemical Pharmacology

Année:

1991

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1991

28

Characterisation of novel indenoindoles. Part II. Redox-recycling with ascorbate

Petter Björquist, Johanna Deinum, Kristina Taure, Christer Westerlund, Ann-Margret Östlund-Lindqvist

Journal:

Biochemical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1996

29

17O hyperfine interaction in the EPR spectrum of fungal laccase A

Johanna S.E. Deinum, Tore Vänngård

Journal:

Année:

1975

Langue:

english

Fichier:

PDF, 272 KB

english, 1975

30

Effect of S-100 proteins and calmodulin on Ca2+-induced disassembly of brain microtubule proteins in vitro

Jacques Baudier, Carin Briving, Johanna Deinum, Kenneth Haglid, Lena Sörskog, Margareta Wallin

Journal:

Année:

1982

Langue:

english

Fichier:

PDF, 280 KB

english, 1982

31

The effect of S-100a and S-100b proteins and Zn2+ on the assembly of brain microtubule proteins in vitro

Johanna Deinum, Jacques Baudier, Carin Briving, Lars Rosengren, Margareta Wallin, Dominique Gerard, Kenneth Haglid

Journal:

Année:

1983

Langue:

english

Fichier:

PDF, 457 KB

english, 1983

32

Interaction of estramustine phosphate with microtubule-associated proteins

Margareta Wallin, Johanna Deinum, Bo Fridén

Journal:

Année:

1985

Langue:

english

Fichier:

PDF, 403 KB

english, 1985

33

Heterogeneous glycosylation patterns of human PAI-1 may reveal its cellular origin

Helén Brogren, Carina Sihlbom, Karin Wallmark, Malin Lönn, Johanna Deinum, Lena Karlsson, Sverker Jern

Journal:

Thrombosis Research

Année:

2008

Langue:

english

Fichier:

PDF, 643 KB

english, 2008

34

Effect of Different Types of Thrombin Inhibitors on Thrombin/Thrombomodulin Modulated Activation of Protein C In Vitro

Christer Mattsson, Angela Menschik-Lundin, Sven Nylander, Erika Gyzander, Johanna Deinum

Journal:

Thrombosis Research

Année:

2001

Langue:

english

Fichier:

PDF, 201 KB

english, 2001

35

Hemodynamic improvement and removal of autoantibodies against β1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy

Reza Mobini, Alexander Staudt, Stephan B. Felix, Gert Baumann, Gert Wallukat, Johanna Deinum, Helen Svensson, Åke Hjalmarson, Michael Fu

Journal:

Journal of Autoimmunity

Année:

2003

Langue:

english

Fichier:

PDF, 143 KB

english, 2003

36

Estramustine Phosphate Inhibits Microtubule Assembly by Binding to the Microtubule-Associated Proteins

MARGARETA WALLIN, JOHANNA DEINUM, BERYL HARTLEY-ASP

Journal:

Annals of the New York Academy of Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 126 KB

english, 1986

37

Conformational differences between latent and active plasminogen activator inhibitor, PAI-1: A spectroscopic study

Stig Boström, Johanna Deinum, Jan-Erik Löfroth, Michael Wirth, Mikael Kubista

Journal:

Thrombosis Research

Année:

1990

Langue:

english

Fichier:

PDF, 592 KB

english, 1990

38

Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637

Deinum, Johanna, Mattsson, Christer, Inghardt, Tord, Elg, Margareta

Journal:

Thrombosis and Haemostasis

Année:

2009

Langue:

english

Fichier:

PDF, 404 KB

english, 2009

39

Identification of Structural–Kinetic and Structural–Thermodynamic Relationships for Thrombin Inhibitors

Winquist, Johan, Geschwindner, Stefan, Xue, Yafeng, Gustavsson, Lars, Musil, Djordje, Deinum, Johanna, Danielson, U. Helena

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 3.93 MB

english, 2013

40

A serendipitously identified novel small molecule procoagulant compound giving rise to a high-throughput screening assay based on human plasma

Gustafsson, David, Nielsen, Sofi, McPheat, Jane, Wågberg, Fredrik, Kaspersson, Karin, Rohman, Mattias, Ulander, Johan, Fex, Tomas, Fjellström, Ola, Deinum, Johanna

Journal:

Thrombosis Research

Année:

2013

Langue:

english

Fichier:

PDF, 957 KB

english, 2013

41

Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens

Neve, Juliette, de Almeida Leone, Priscila, Carroll, Anthony R., Moni, Roger W., Paczkowski, Natalii J., Pierens, Greg, Björquist, Petter, Deinum, Johanna, Ehnebom, Johanna, Inghardt, Tord, Guymer, Go

Journal:

Journal of Natural Products

Année:

1999

Langue:

english

Fichier:

PDF, 55 KB

english, 1999

42

A Novel Surface Modification Using Tissue Factor Reconstituted in Phospholipid Vesicles for the Activation of Blood Coagulation

Svedhem, Sofia, Wikström, Angelica, Deinum, Johanna, Kasemo, Bengt, Hansson, Kenny

Journal:

Journal of Biomaterials Science Polymer Edition

Année:

2009

Langue:

english

Fichier:

PDF, 294 KB

english, 2009

43

Monitoring of Protein Conformational Changes Upon Interaction with Low Molecular Weight Compounds by QCM-D and its Application to Drug Discovery

Nilebäck, Erik, Westberg, Fredrik, Deinum, Johanna, Svedhem, Sofia

Journal:

Biophysical Journal

Année:

2011

Langue:

english

Fichier:

PDF, 68 KB

english, 2011

44

Effect of cibacron blue on tubulin assembly in the absence and presence of microtubule-associated proteins

Deinum, Johanna, Sörskog, Lena, Wallin, Margareta

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

1982

Langue:

english

Fichier:

PDF, 983 KB

english, 1982

45

Molecular weight dependency of heparin inhibition of microtubule assembly in vitro

Deinum, Johanna, So¨rskog, Lena, Wallin, Margareta, Dahlba¨ck, Johan

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

1984

Langue:

english

Fichier:

PDF, 260 KB

english, 1984

46

The binding of Ruthenium red to tubulin

Deinum, Johanna, Wallin, Margareta, Jensen, Palle Waage

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

1985

Langue:

english

Fichier:

PDF, 615 KB

english, 1985

47

Changes in the hydrodynamic properties of microtubules induced by taxol

Wallin, Margareta, Nodh, Jerker, Deinum, Johanna

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

1986

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1986

48

Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIa †

Buchanan, Malcolm S., Carroll, Anthony R., Wessling, Deborah, Jobling, Michael, Avery, Vicky M., Davis, Rohan A., Feng, Yunjiang, Xue, Yafeng, Öster, Linda, Fex, Tomas, Deinum, Johanna, Hooper, John

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 589 KB

english, 2008

49

Viscoelastic Sensing of Conformational Changes in Plasminogen Induced upon Binding of Low Molecular Weight Compounds

Nilebäck, Erik, Westberg, Fredrik, Deinum, Johanna, Svedhem, Sofia

Journal:

Analytical Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2010

50

Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

Björquist, Petter, Ehnebom, Johanna, Inghardt, Tord, Hansson, Lennart, Lindberg, Maria, Linschoten, Marcel, Strömqvist, Mats, Deinum, Johanna

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 121 KB

english, 1998